Mayo Clinic performs a genetic feat; switches zebrafish genes on and off

Researchers at Rochester, Minnesota-based Mayo Clinic have designed a new tool for identifying protein function […]

Researchers at Rochester, Minnesota-based Mayo Clinic have designed a new tool for identifying protein function from genetic code after successfully switching individual genes off and on in zebrafish, and then observing embryonic and juvenile development, the Clinic announced Monday.

The feat has the potential to provide insight into how cancerous cells spread, what makes some people more prone to heart attacks, or how genes play a role in addiction. Other more complex issues, such as the genetics of behavior, plasticity and cellular memory, stress, learning and epigenetics, could also be studied with this method.

The study examines protein expression and function from 350 loci among the zebrafish’s approximately 25,000 protein-encoding genes. Researchers plan to identify another 2,000 loci.

“I consider this particular system a toolbox for answering fundamental scientific questions,” says Dr. Stephen Ekker, a Mayo Clinic molecular biologist and lead author of the the study that appears in the journal Nature Methods, about this current medical news. “This opens up the door to a segment of biology that has been impossible or impractical with existing genomics research methods.”

About 50,000 fish are maintained in the Zebrafish Core Facility at the Mayo Clinic.

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